Study aims to develop a machine learning mode

Alexandria, VA – At the AADOCR’s 52nd Annual Meeting and Exposition, held in conjunction with the 47th CADR Annual Meeting, a study was presented that aims to develop a machine learning model to predict cardiovascular disease using indicators of to develop and test oral infections. The AADOCR/CADR Annual Meeting & Exhibition took place March 15-18, 2023 at the Oregon Convention Center in Portland.

The study, led by Dylan Joseph Baxter of the University of Pittsburgh, analyzed the association between self-reported cardiovascular disease (heart surgery, heart valves, heart murmurs, irregular heartbeat and congenital heart disease) and markers of oral infection in 5,188 dental and DNA subjects -Repository project of the University of Pittsburgh School of Dental Medicine. Periodontal screening and recording data (PSR) available from 740 subjects and the carious, missing or filled teeth and surfaces (DMFT and DMFS) from 5010 subjects were used in the analyses.

Results indicated a significant association between both DMFT and DMFS and cardiovascular disease independent of gender and tobacco use. The results of the analysis of covariance between DMFS and cardiovascular disease remained significant even after controlling for participants’ age (p-value = 0.0027). The machine learning model predicted whether a subject had cardiovascular disease based on their DMFS score with an in-registry accuracy of 84.3%.

The study confirmed the link between dental caries and cardiovascular disease and highlighted the potential of machine learning methods to improve the prediction of cardiovascular disease using indicators of oral infection. Future directions include evaluating whether artificial intelligence methods can help predict improvement in cardiovascular disease markers in the context of caries management.

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This research was presented as part of the interactive presentation “Machine Learning Model for Cardiovascular Disease Prediction Using Indicators of Oral Infections” held on Wednesday, March 15, 2023 at 14:20 Pacific Daylight Time (UTC-07:00) during of the session “Clinical and Translational Science Network III: Advances in Oral Disease Mechanisms and the Connection with Systemic Condition” from 13:30 – 15:00

The American Association for Dental, Oral, and Craniofacial Research (AADOCR) is a nonprofit organization dedicated to advancing dental, oral, and craniofacial research to advance health and well-being. AADOCR represents the individual scientists, clinical scientists, dentists and students from academic, government, nonprofit and private institutions who share our mission. AADOCR is the largest division of the International Association for Dental Research. Learn more at

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